Detailed view for TVAG_315300

Basic information

TDR Targets ID: 857187
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 10.4032 | Length (AA): 180 | MW (Da): 21282 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06102   rRNA biogenesis protein RRP36

Gene Ontology

Mouse over links to read term descriptions.
GO:0000469   cleavages during rRNA processing  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129107)

Species Accession Gene Product
Arabidopsis thaliana AT1G12650   hypothetical protein
Babesia bovis BBOV_III009460   conserved hypothetical protein
Brugia malayi Bm1_19725   C6orf153 protein
Candida albicans CaO19.9898   similar to S. cerevisiae YOR287, possible coil-coil protein involved in pre-rRNA processing
Candida albicans CaO19.2362   similar to S. cerevisiae YOR287, possible coil-coil protein involved in pre-rRNA processing
Cryptosporidium hominis Chro.30026   hypothetical protein
Cryptosporidium parvum cgd3_170   hypothetical protein
Dictyostelium discoideum DDB_G0278751   hypothetical protein
Drosophila melanogaster Dmel_CG8461   CG8461 gene product from transcript CG8461-RA
Echinococcus granulosus EgrG_001079000   rRNA biogenesis protein RRP36
Entamoeba histolytica EHI_007980   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_001079000   rRNA biogenesis protein RRP36
Giardia lamblia GL50803_33809   Hypothetical protein
Homo sapiens ENSG00000124541   ribosomal RNA processing 36 homolog (S. cerevisiae)
Loa Loa (eye worm) LOAG_06184   hypothetical protein
Mus musculus ENSMUSG00000023971   ribosomal RNA processing 36 homolog (S. cerevisiae)
Neospora caninum NCLIV_018980   hypothetical protein, conserved
Oryza sativa 4347627   Os09g0525200
Onchocerca volvulus OVOC6028  
Plasmodium berghei PBANKA_0203900   rRNA biogenesis protein RRP36, putative
Plasmodium falciparum PF3D7_0109700   rRNA biogenesis protein RRP36, putative
Plasmodium knowlesi PKNH_0204100   rRNA biogenesis protein RRP36, putative
Plasmodium vivax PVX_081305   hypothetical protein, conserved
Saccharomyces cerevisiae YOR287C   Rrp36p
Schistosoma japonicum Sjp_0029870   expressed protein
Schistosoma mansoni Smp_026300   hypothetical protein
Schmidtea mediterranea mk4.001361.01  
Toxoplasma gondii TGME49_244420   hypothetical protein
Theileria parva TP04_0856   hypothetical protein
Trichomonas vaginalis TVAG_315300   conserved hypothetical protein
Trichomonas vaginalis TVAG_330960   conserved hypothetical protein

Essentiality

TVAG_315300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
YOR287C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0203900 Plasmodium berghei Slow plasmo
TGME49_244420 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_315300 (Trichomonas vaginalis), conserved hypothetical protein
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